BH3-Only Molecule Bim Mediates -Cell Death in IRS2 Deficiency
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چکیده
منابع مشابه
BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency
Irs2-deficient mice develop type 2-like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order to define the molecular mechanisms, we knocked down Irs2 gene expression in mouse MIN6 insulinoma cells. Insulin receptor substrate 2 (IRS2) suppression induced apoptotic cell death, which was associ...
متن کاملRole of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency
Mutations in pancreatic duodenal homeobox-1 (PDX1) are associated with diabetes in humans. Pdx1-haploinsufficient mice develop diabetes due to an increase in β-cell death leading to reduced β-cell mass. For definition of the molecular link between Pdx1 deficiency and β-cell death, Pdx1-haploinsufficient mice in which the genes for the BH3-only molecules Bim and Puma had been ablated were studie...
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Acute heat shock can induce apoptosis through a canonical pathway involving the upstream activation of caspase-2, followed by BID cleavage and stimulation of the intrinsic pathway. Herein, we report that the BH3-only protein BIM, rather than BID, is essential to heat shock-induced cell death. We observed that BIM-deficient cells were highly resistant to heat shock, exhibiting short and long-ter...
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www.landesbioscience.com Cell Cycle 3453 Members of the Bcl-2 protein family that contain only the Bcl-2 homology (BH) domain 3 are inducers of cell death when overexpressed. One of these BH3only proteins, Bmf, was discovered because of its binding to the anti-apoptotic member Bcl-2, BclXL , Bcl-w, and Mcl-1. It is expressed in the pancreas, liver, kidney, and hematopoietic tissues and in many ...
متن کاملPuma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
The physiological role of B cell lymphoma 2 (Bcl-2) homology 3-only proteins has been investigated in mice lacking the individual genes identifying rate-limiting roles for Bim (Bcl-2-interacting mediator of cell death) and Puma (p53-up-regulated modulator of apoptosis) in apoptosis induction. The loss of Bim protects lymphocytes from apoptosis induced by cytokine deprivation and deregulated Ca+...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2014
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db13-1814